DEVELOPMENT OF TRANSDERMAL PATCH CONTAINING LONGAN SEED EXTRACT
The purpose of this study was to develop transdermal patch containing longan seed extract for the treatment of joint inflammation. Transdermal delivery systems (TDSs) also known as transdermal patch was developed in order to increase the efficacy of drugs or active substances via skin. TDSs are dosage forms involving the control of active compounds through the skin for local or systemic therapeutic effect and suited for the treatment of chronic disorder. Longan seed extract contains many flavonoid and phenolic compounds that possess anti-inflammatory activity by inhibiting the matrix metalloproteinase enzymes (pro-MMP-2 and pro-MMP-9 induced MMP-2 and MMP-9) in human synovial cells that relate to the cause of rheumatoid arthritis with the joint inflammation. Firstly, the hydrogel matrix system was developed by the casting method, using various types and concentrations of bioadhesive polymers and plasticizers. Hydroxyl propyl methyl cellulose (HPMC), combined with chitosan and PVP K-90 in various ratios, was used as polymer system. Propylene glycol, polyethylene glycol-400 (PEG 400) or glycerine was used as plasticizer and DMSO, oleic acid or lemon oil as penetration enhancer. These were then evaluated for their physical properties such as appearance, pH and thickness. The mechanical properties such as tensile strength and percentage elongation at break were also determined. The results revealed that the formulation containing squid HPMC, chitosan and PVP K-90 (12:3:1) with PEG 400 showed the most optimal physical characteristics with the highest tensile strength and percentage elongation at break. Therefore, this was then selected for longan seed extract inclusion. The release profile as well as clinical evaluation will be further investigated.
Preedalikit, W., Leelapornpisid, P. and Vinijketkhumnua, U. (2014). DEVELOPMENT OF TRANSDERMAL PATCH CONTAINING LONGAN SEED EXTRACT . Acta Hortic. 1023, 179-184
hydrogel, matrix metalloproteinase enzymes, joint inflammation, hydrophilic polymer