Molecular mechanisms underlying pyrethroid resistance in dengue mosquito vectors collected from Singapore
Singapore is a Southeast Asian island with a tropical rainforest climate and no distinctive seasons. Despite having well-organized national vector control programs, this country continues to face the risk of mosquito-borne diseases, such as dengue and chikungunya fevers. Successful vector control is important for preventing epidemics of these infectious diseases. Pyrethroids were once the most effective insecticides used against adult mosquitoes. However, the development of insecticide resistance against pyrethroids has made it more challenging to control the adult mosquito population effectively. A deeper understanding of the molecular mechanisms underlying pyrethroid resistance will facilitate the development of new strategies to overcome this resistance. We herein review studies on the status of pyrethroid susceptibilities and mechanisms of resistance in vectors of dengue and chikungunya fevers in Singapore.
Kasai, S., Hirata, K., Komagata, O., Itokawa, K. and Tomita, T. (2017). Molecular mechanisms underlying pyrethroid resistance in dengue mosquito vectors collected from Singapore. Acta Hortic. 1169, 87-92
voltage-sensitive sodium channel, Vssc, kdr, Aedes aegypti, Aedes albopictus, cytochrome P450 monooxygenase