It's not a gut feeling - fruit and vegetables do have prebiotic-like effects
It is now widely accepted that fruit and vegetables (FAV) are providing many health benefits. Indeed, epidemiological and intervention clinical studies have shown that regular consumption of FAV prevent or reduce the incidence of many disorders and illnesses like cardiovascular diseases, obesity, metabolic syndrome, diabetes, cancer, and neurodegenerative diseases. FAV are rich sources of minerals, vitamins, fibers and phytonutrients and they are especially rich in polyphenols. These molecules display strong antioxidant activity in vitro, but less so in vivo. There is thus much debate on the exact mode of action of these bioactive molecules on health. Polyphenols have a very low bioavailability and are subject to extensive phase I and II metabolism once in circulation. Moreover, more than 95% of these molecules reach the colon intact where they can modulate the gut microbiota and prevent dysbiosis. We have recently shown that berry polyphenols can strongly alter the gut microbiota and favor the development of a beneficial gut microbial community. In particular, they can stimulate the growth of a mucus inhabiting bacteria called Akkermansia municiphila, coined the anti-obesity bacteria. This bacterium has been associated with reduction of gut leakiness, modification of the bile acid metabolism and attenuation of low-grade inflammation. We will thus present in this conference results to support new modes of action of FAV on the gut microbiota and in turn, show how microbiota homeostasis may prevent many chronic diseases.
Desjardins, Y. (2020). It's not a gut feeling - fruit and vegetables do have prebiotic-like effects. Acta Hortic. 1292, 337-344
phytochemicals, antioxidants, chronic diseases, inflammation, diabetes, obesity, microbiota, bile acids, cranberry, camu-camu