ANTILEISHMANIAL PROPERTIES OF ALLIUM SATIVUM EXTRACTS AND DERIVATIVES
Allicin (diallyl thiosulfinate), the active antimicrobial compound in Allium sativum, demonstrates significant inhibition of leishmanial cell growth. The growth of Leishmania Mexican and Leishmania chagasi was inhibited by introduction of pure allicin into the culture wells. Growth was measured through turbidimetric analysis. HeLa and CEM-T4 human cells were indicators of mammalian cell toxicity. Allicin was much less inhibitory to the growth of either mammalian cell lines. Allyl sulfide, diallyl disulfide, diallyl trisulfide, ajoene and fresh and boiled extracts of A. sativum were also examined as potential anti-leishmanial chemotherapeutic agents.
McClure, C. D., Nolan, Linda L. and Zatyrka, Simon A. (1996). ANTILEISHMANIAL PROPERTIES OF ALLIUM SATIVUM EXTRACTS AND DERIVATIVES. Acta Hortic. 426, 183-192
allicin, Allium sativum, chemotherapeutic, leishmaniasis