ANTICONVULSANT PROPERTIES OF LINALOOL AND γ-DECANOLACTONE IN MICE

E. Elisabetsky, G.P. Coelho de Souza
Several essential oil producing species are used as anticonvulsant in traditional medical systems. Aeollanthus suaveolens (Lamiaceae) is used by "caboclos" in the Brazilian Amazon in home made antiepileptic formulations, which lead to its ethnopharmacological exploration. Initial studies pointed to the species essential oil as the source of active compounds. Combining the rational basis of ethnopharmacology and chemotaxonomy, a coordinated psychopharmacological and phytochemical approach was used.

We have studied the main components from A. suaveolens essential oils, as well as structurally related compounds, in several experimental models of epileptic activity. Linalool and gamma-decanolactone have been identified as active compounds and their anticonvulsant profile and mechanism of action are being completed. We present and discuss the significance of results obtained to this date, which include: a) the anticonvulsant activity of linalool against pentylenetetrazol (PTZ), maximal electroshock seizures in mice, as well as linalool interaction with classical anticonvulsants in these models, and linalool inhibitory effect on [3H] glutamate binding in rat cortex membranes, b) the anticonvulsant activity of gamma-decanolactone against pentylenetetrazol (PTZ) and maximal electroshock seizures in mice, and gamma-decanolactone inhibitory effect on [3H] glutamate binding in rat cortex membranes. Data is compared to classical anticonvulsants, in relation to anticonvulsant and antiepileptogenic properties, and possible mechanisms of action.

A comprehensive report of this long-term ongoing study provides an opportunity to scrutinize aspects of the ethnopharmacological approach and methodologies.

Elisabetsky, E. and Coelho de Souza, G.P. (1999). ANTICONVULSANT PROPERTIES OF LINALOOL AND γ-DECANOLACTONE IN MICE. Acta Hortic. 501, 227-234
DOI: 10.17660/ActaHortic.1999.501.36
https://doi.org/10.17660/ActaHortic.1999.501.36
linalool, γ-decanolactone, Aeollanthus suaveolens, anticonvulsants

Acta Horticulturae