ANTICONVULSANT PROPERTIES OF LINALOOL AND γ-DECANOLACTONE IN MICE
We have studied the main components from A. suaveolens essential oils, as well as structurally related compounds, in several experimental models of epileptic activity. Linalool and -decanolactone have been identified as active compounds and their anticonvulsant profile and mechanism of action are being completed. We present and discuss the significance of results obtained to this date, which include: a) the anticonvulsant activity of linalool against pentylenetetrazol (PTZ), maximal electroshock seizures in mice, as well as linalool interaction with classical anticonvulsants in these models, and linalool inhibitory effect on [3H] glutamate binding in rat cortex membranes, b) the anticonvulsant activity of -decanolactone against pentylenetetrazol (PTZ) and maximal electroshock seizures in mice, and -decanolactone inhibitory effect on [3H] glutamate binding in rat cortex membranes. Data is compared to classical anticonvulsants, in relation to anticonvulsant and antiepileptogenic properties, and possible mechanisms of action.
A comprehensive report of this long-term ongoing study provides an opportunity to scrutinize aspects of the ethnopharmacological approach and methodologies.