THE TRADITIONAL USE OF THE LATEX FROM EUPHORBIA TIRUCALLI LINNAEUS (EUPHORBIACEAE) IN THE TREATMENT OF CANCER IN SOUTH BRAZIL
The prevalent constituents of this plant latex are diterpenes from the tigliane (phorbol esters) and from the ingenane types (ingenol esters). The cancer management with Euphorbia tirucalli Linn. presents no scientifical basis, at least up to the moment, since the phorbol esters have already presented tumor-promoting ability. Good examples of the last statement are the prototypes TPA (12-O-tetradecanoyl phorbol-13-acetate) and de 4-deoxyphorbol that induce the Burkitt's lymphoma and the nasopharyngeo carcinoma development, which are endemical in places where the plant Euphorbia tirucalli is widely distributed in the environment.