LYCOPENE INTAKE SIGNIFICANTLY REDUCES BIOMARKERS OF OXIDATIVE STRESS AND BONE RESORPTION IN POSTMENOPAUSAL WOMEN

L.G. Rao, E.S. Mackinnon, A.V. Rao
Oxidative stress induced by reactive oxygen species (ROS) has now been associated with the risk of osteoporosis, and certain antioxidants were shown epidemiologically to counteract this risk. We studied the role of lycopene, a potent carotenoid antioxidant found in tomatoes and tomato products, in decreasing the risk of osteoporosis in postmenopausal women. Postmenopausal women aged 50–60 years were recruited to participate in the study. They were asked to provide a seven-day dietary records and fasting blood samples. Serum samples were used to measure serum lycopene, oxidative stress parameters and bone turn-over markers. The serum lycopene per kilogram body weight of the participants was grouped into quartiles and correlated with the measured serum parameters using one-way ANOVA and the Newman-Keuls post-test. The results of our study showed that groups with higher dietary lycopene intake correlated directly with serum lycopene (p<0.02). A higher serum lycopene was found to be associated with a low NTx (p<0.005) and higher protein thiol or lower protein oxidation (p<0.05). In conclusion, our findings suggest that the dietary antioxidant lycopene may reduce the risk of osteoporosis in postmenopausal women.
Rao, L.G., Mackinnon, E.S. and Rao, A.V. (2007). LYCOPENE INTAKE SIGNIFICANTLY REDUCES BIOMARKERS OF OXIDATIVE STRESS AND BONE RESORPTION IN POSTMENOPAUSAL WOMEN. Acta Hortic. 758, 199-204
DOI: 10.17660/ActaHortic.2007.758.23
https://doi.org/10.17660/ActaHortic.2007.758.23
lycopene, postmenopausal osteoporosis, bone turnover markers, antioxidant capacity, oxidative stress, reactive oxygen species
English

Acta Horticulturae