ANTIMICROBIAL ACTIVITY OF DATE PALM (PHOENIX DACTYLIFERA) PITS EXTRACTS AND ITS ROLE IN REDUCING THE SIDE EFFECT OF METHYL PREDNISOLONE ON SOME NEUROTRANSMITTER CONTENT IN THE BRAIN, HORMONE TESTOSTERONE IN ADULTHOOD

The present work was carried out to study the impact of date palm pits’ antibacterial activities on two species of pathogenic bacteria (Klebsiella pneumonia and Escherichia coli) and its role in reducing the side effect of methylprednisolone on some neurotransmitter content in the brain, hormone testosterone and testculture of male albino rats. Date palm pits are most effective in inhibiting growth of bacteria as compared with antibiotics due to differences in resistance of bacteria to anti-tested materials due to the change in membrane permeability of cells, thereby hindering the entry of enzymes or excreted by the change in the chemical composition of the constituent chemical. The results showed that the daily oral administration of pits of date palm caused the maximal increase in NE, DA and GABA content that was found in the brain stem after 2 weeks. The daily oral administration of methylprednisolone caused a decrease in NE, DA and GABA content found in the brain stem after 2 weeks. Moreover, the daily oral administration of pits of date palm and methylprednisolone caused an increase in NE content found in the brain stem after 2 weeks. The daily oral administration of pits of date palm and methylprednisolone caused a significant increase in testosterone level in serum blood of male albino rats. From the present results, it is clear that the effect of chronic oral administration of methylprednisolone and pits of data palm caused a recovery effect on testicles of male albino rats, noticing the high sperm in some tubules and tubular partial late spermatogenic arrest (spermatide level) is only seen in 10-20% of tubules.
The appropriate recommendations in this study are to use nuclei dates antimicrobial on Klebsiella pneumonia and Escherichia coli than the activity of standard antibiotics and the results concluded that using intended date palm pits as a preventive measure to reduce the side effects resulting from the use of a drug methylprednisolone on the some neurotransmitter content in the brain. The hormone testosterone was determined in a testculture of male albino rats.