Articles
NEUROPROTECTIVE ACTIVITY OF TASSEL FLOWER (EMILA SONCHIFOLIA)
Article number
1023_18
Pages
129 – 135
Language
English
Abstract
A phytochemical study on the ethanol extract of tassel flower (Emilia sonchifolia) led to the isolation of senecionine-N-oxide (1), kaempferol 3-O-rutinoside (2) and protocatechuic acid (3). The structures of these compounds were determined using spectroscopic analyses (UV, NMR and MS), with comparison of their spectral data with previously reported values.
These compounds were reported for the first time for this plant.
Neuroprotective properties of the ethanol extract and the isolated compounds were examined using antioxidant, cytoprotective, anti-inflammatory and acetylcholin-esterase inhibitory assays.
Antioxidant activity was evaluated using ferric reducing antioxidant power (FRAP), β-carotene bleaching and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays.
Compounds 2 and 3 displayed profound antioxidant capacities.
Compound 2 elicited high cytoprotection with the percentage of protection 56.62% and significant inhibition of 5-lipoxygenase (5-LOX) activities with IC50 44.59 μg ml-1. Compound 2 is also acetylcholinesterase inhibitor.
These compounds were reported for the first time for this plant.
Neuroprotective properties of the ethanol extract and the isolated compounds were examined using antioxidant, cytoprotective, anti-inflammatory and acetylcholin-esterase inhibitory assays.
Antioxidant activity was evaluated using ferric reducing antioxidant power (FRAP), β-carotene bleaching and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays.
Compounds 2 and 3 displayed profound antioxidant capacities.
Compound 2 elicited high cytoprotection with the percentage of protection 56.62% and significant inhibition of 5-lipoxygenase (5-LOX) activities with IC50 44.59 μg ml-1. Compound 2 is also acetylcholinesterase inhibitor.
Authors
W. Sumi, K.T. Jin, T.K. Nee, W. Christophe
Keywords
antioxidant, cytoprotective, anti-inflammatory, acetylcholinesterase inhibitor
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