Harpagide and related iridoid glycosides in vegetative tissues of cultivated Scrophularia lanceolata and Scrophularia marilandica
Scrophularia lanceolata and S. marilandica are herbaceous North American perennials that were used medicinally by Native Americans and early colonialists. We are cultivating these species under defined field conditions in Missouri, USA, and have assessed the content of harpagide and related iridoid glycosides to which various anti-inflammatory and nociceptive activities have been ascribed. Harpagide and its derivatives, 8-O-trans cinnamoyl harpagide (harpagoside), 8-O-coumaryl harpagide, and 8-O-acetyl harpagide, as determined by HPLC and UPLC-MS, constitute between 0.8-1.0% of the dry weight of the collective stems, leaves, and roots collected from field-grown plants. Significant differences in the occurrence of these four iridoid glycosides were noted between the two species, among the three vegetative tissues studied, and across the growing season.
Brownstein, K.J., Thomas, A.L., Rottinghaus, G.E., Lynch, B.A., Gang, D.R. and Folk, W.R. (2016). Harpagide and related iridoid glycosides in vegetative tissues of cultivated Scrophularia lanceolata and Scrophularia marilandica. Acta Hortic. 1125, 83-90
acetyl harpagide, coumaroyl harpagide, figwort, harpagoside, monoterpene