Articles
PHARMACOGNOSTICAL STUDIES ON THE ROOTS OF PIPER NIGRUM L. II: CHEMICAL AND PHARMACOLOGICAL STUDIES
Article number
426_20
Pages
175 – 178
Language
Abstract
Three amide alkaloids of Piper nigrum L. such as piperine, pellitorine, 3,4-dimethyinenedioxycinnamoyl-piperidine, and ß-sitesterol were isolated from the ethanol extract, purified and identified.
Pharmalogical experiments showed that the ethanol extract had anticonvulusive, sedative, and analgesic activities to mice at the dosage level 2 g/kg orally.
LD50 of the ethanol and the water extracts to mice were respectively 12.66 and 424.38 g/kg converted into crude material.
Pharmalogical experiments showed that the ethanol extract had anticonvulusive, sedative, and analgesic activities to mice at the dosage level 2 g/kg orally.
LD50 of the ethanol and the water extracts to mice were respectively 12.66 and 424.38 g/kg converted into crude material.
Authors
S. Hu, P. Ao, H. Tan
Keywords
Pepper root, Piper nigrum L., amide alkaloids, phytochemistry, bioactivities
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